| Item type |
学術雑誌論文 / Journal Article.(1) |
| 公開日 |
2022-03-30 |
| 書誌情報 |
en : Biochemistry and Biophysics Reports
巻 29,
p. 101189,
発行日 2022
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| タイトル |
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|
タイトル |
Amyloid β aggregation induces human brain microvascular endothelial cell death with abnormal actin organization |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Amyloid β |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Blood-brain barrier |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cerebral amyloid angiopathy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Endothelial cell |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Quantum dots |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
TAKE, Yushiro
CHIKAI, Yusaku
島森, 圭弥
倉賀野, 正弘
KURITA, Hiroki
徳樂, 清孝
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| 室蘭工業大学研究者データベースへのリンク |
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表示名 |
徳樂 清孝（TOKURAKU Kiyotaka） |
|
URL |
http://rdsoran.muroran-it.ac.jp/html/100000137_ja.html |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Cerebral amyloid angiopathy (CAA) is a disease in which amyloid β (Aβ) is deposited on the walls of blood vessels in the brain, making those walls brittle and causing cerebral hemorrhage. However, the mechanism underlying its onset is not well understood. The aggregation and accumulation of Aβ cause the occlusion and fragility of blood vessels due to endothelial cell damage, breakdown of the blood-brain barrier, and replacement with elements constituting the blood vessel wall. In this study, we observed the effect of Aβ on human primary brain microvascular endothelial cells (hBMECs) in real-time using quantum dot nanoprobes to elucidate the mechanism of vascular weakening by Aβ. It was observed that Aβ began to aggregate around hBMECs after the start of incubation and that the cells were covered with aggregates. Aβ aggregates firmly anchored the cells on the plate surface, and eventually suppressed cell motility and caused cell death. Furthermore, Aβ aggregation induced the organization of abnormal actin, resulting in a significant increase in intracellular actin dots over 10 μm2. These results suggest that the mechanism by which Aβ forms a fragile vessel wall is as follows: Aβ aggregation around vascular endothelial cells anchors them to the substrate, induces abnormal actin organization, and leads to cell death. |
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言語 |
en |
| 出版者 |
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出版者 |
ELSEVIER |
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言語 |
en |
| 出版者版へのリンク |
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表示名 |
10.1016/j.bbrep.2021.101189 |
|
URL |
https://doi.org/10.1016/j.bbrep.2021.101189 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1016/j.bbrep.2021.101189 |
| 日本十進分類法 |
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主題Scheme |
NDC |
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主題 |
493 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2405-5808 |
| 権利 |
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|
言語 |
en |
|
権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
Biochemistry_29_101189 (5.5 MB)
