Zeolite-Supported molybdenum catalysts were prepared by chemical vapor deposition (CVD) method using Mo(CO)₆, and their catalytic activities for the hydrodesulfurization of thiophene were examined at 400⁰C. It was revealed that Mo(CO)₆/Ni⁰Y followed by sulfiding with H₂S showed higher catalytic activity than commercial CoMo/Al₂0₃ catalysts. There is a possibility of use of Mo(CO)₆/Ni⁰Y as highly active second generation hydrodesulfurization catalyst for petroleum feedstocks.