Today, everyone obviously knows that tobacco smoking is not healthy and harmful. However, it is very regrettable that some college students fall into a habit of tobacco smoking. So, the primary purpose of this study is to research the prevalence of tobacco smoking in Muroran Institute of Technology . The secondary is to examine relationship between tobacco smoking and health locus of control. A questionnaire for this research was composed of fourteen items asking about smoking and twenty-five items of Japanese Health Locus of Control scale(JHLC). At a regular physical examination in April, 2006, the research was conducted with 2075 students, and 1840 was valid. In results, we found overall smoking rate of 28.7%. Males (29.6%) were lower than the Japanese second decades’s average of male. Otherwise, females (20.5%) were a little higher than that of female. And, non-smokers were more likely to control their health by themselves than smokers, but it was not so significant. For smoking cessation of all-campus, further studies will be needed.