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Biotransformation of organic compounds in vivo using larvae of beetles (Allomyrina dichotoma) as biocatalysts
http://hdl.handle.net/10258/3823
http://hdl.handle.net/10258/3823e4ea8e60-d73e-49df-adbc-6dcfebc58fed
名前 / ファイル | ライセンス | アクション |
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Biocatalysis_and_Agricultural_Biotechnology.pdf (1.0 MB)
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Item type | 学術雑誌論文 / Journal Article.(1) | |||||||||||||||||
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公開日 | 2015-11-04 | |||||||||||||||||
タイトル | ||||||||||||||||||
言語 | en | |||||||||||||||||
タイトル | Biotransformation of organic compounds in vivo using larvae of beetles (Allomyrina dichotoma) as biocatalysts | |||||||||||||||||
言語 | ||||||||||||||||||
言語 | eng | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Beetle larvae | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Biotransformation | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Allylicoxidation | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Biocatalyst | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Regiospecific dihydroxylation | |||||||||||||||||
資源タイプ | ||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
資源タイプ | journal article | |||||||||||||||||
アクセス権 | ||||||||||||||||||
アクセス権 | open access | |||||||||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||
著者 |
上井, 幸司
× 上井, 幸司
WEKO
911
× 奥山, 祐子× 中野, 博人
WEKO
59463
× FURUKAWA, Kanako× HIROSHIMA, Eriko× AZUMA, Hiroko× WATANABE, Masataka× MATSUMOTO, Takatoshi× 常盤, 峻士× 竹下, 光弘 |
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室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||
上井 幸司(UWAI Koji) | ||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000240_ja.html | ||||||||||||||||||
室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||
中野 博人(NAKANO Hiroto) | ||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000161_ja.html | ||||||||||||||||||
抄録 | ||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||
内容記述 | The biotransformation of organic compounds using the larvae of the Japanese rhinoceros beetle (Allomyrina dichotoma) as a biocatalyst is described. When phenyl alkanediones were administered by mouth (p.o) or subcutaneous injection (s.c) to the beetle, asymmetric reduction occurred to yield the corresponding diols in varying optical yields: 1-phenyl-1,2-propandione or 1-phenyl-1,3-butanedione reduced to (1R,2S)- and (1S,2S)-1,2-phenylpropanediols in high optical yields or (1R,3S)- and (1R,3R)-1-phenyl-1,3-butanediols in low to high optical yields, respectively. By administrating 1-phenyl-1-propanone, 1-phenyl-1-butanone or 4-phenyl-2-butanone, redox reactions occurred to give 1-phenyl-1,2-propanediols or 1-phenyl-1,3-butanediols in lower optical yields. The administrations of β-ionone and cinnamyl chloride resulted in regioselective allylic oxidations producing enone and cinnamic acid, respectively. However, when (R)-(-)-carvone was administered, regiospecific dihydroxylation at the isopropenyl group occurred to give (4R,8R)- and (4R,8S)-8,9-dihydroxy-8,9-dihydrocarvone as diastereoisomers. These results appear to demonstrate similar reaction tendency with the case of a microorganism. It is possible that these reactions were due in part to bacteria in the intestine of the larva: however, regio- and stereoselectivities of the reactions were sometimes unique. Thus, it is supposed that these biotransformations were accomplished by the ensemble of the larva׳s own enzymes with several bacteria. The results obtained in this study might show the possibility of using such enzymes derived from insects, including beetle larvae, as a biocatalyst. | |||||||||||||||||
言語 | en | |||||||||||||||||
書誌情報 |
en : Biocatalysis and agricultural biotechnology 巻 3, 号 4, p. 129-133, 発行日 2014-10 |
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出版者 | ||||||||||||||||||
言語 | en | |||||||||||||||||
出版者 | Elsevier Ltd. | |||||||||||||||||
出版者版へのリンク | ||||||||||||||||||
10.1016/j.bcab.2014.09.005 | ||||||||||||||||||
https://doi.org/10.1016/j.bcab.2014.09.005 | ||||||||||||||||||
DOI | ||||||||||||||||||
関連タイプ | isVersionOf | |||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||
関連識別子 | 10.1016/j.bcab.2014.09.005 | |||||||||||||||||
論文ID(NAID) | ||||||||||||||||||
関連タイプ | isVersionOf | |||||||||||||||||
識別子タイプ | NAID | |||||||||||||||||
関連識別子 | 120005668492 | |||||||||||||||||
日本十進分類法 | ||||||||||||||||||
主題Scheme | NDC | |||||||||||||||||
主題 | 579 | |||||||||||||||||
ISSN | ||||||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||||||
収録物識別子 | 18788181 | |||||||||||||||||
権利 | ||||||||||||||||||
言語 | en | |||||||||||||||||
権利情報 | ©2014 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||
著者版フラグ | ||||||||||||||||||
出版タイプ | AM | |||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
フォーマット | ||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||
内容記述 | application/pdf |