@article{oai:muroran-it.repo.nii.ac.jp:00010210,
 author = {田口, 莉帆 and TAGUCHI, Riho and 畑山, 晃輝 and HATAYAMA, Koki and 高橋, 倫人 and TAKAHASHI, Tomohito and HAYASHI, Takafumi and SATO, Yuki and 佐藤, 大輔 and SATO, Daisuke and OTA, Kiminori and 中野, 博人 and NAKANO, Hiroto and SEKI,  Chigusa and 関, 千草 and ENDO, Yasuyuki and TOKURAKU, Kiyotaka and 徳樂, 清孝 and UWAI,  Koji and 上井, 幸司},
 journal = {European Journal of Medicinal Chemistry},
 month = {Sep},
 note = {application/pdf, Amyloid-β aggregation inhibitors are expected to be therapeutic or prophylactic agents for Alzheimer's disease. Rosmarinic acid, which is one of the main aggregation inhibitors derived from Lamiaceae, was employed as a lead compound and its 25 derivatives were synthesized. In this study,the structure-activity relations of rosmarinic acid derivatives for the amyloid-β aggregation inhibitory effect (MSHTS assay), antioxidant properties, and xanthine oxidase inhibition were evaluated. Among the tested compounds, compounds 16d and 19 were found to the most potent amyloid aggregation inhibitors. The SAR revealed that the necessity of the presence of the phenolic hydroxyl on one side of the molecule as well as the lipophilicity of the entire molecule. The importance of these structural properties was also supported by docking simulations.},
 pages = {1066--1075},
 title = {Structure-activity relations of rosmarinic acid derivatives for the amyloid β aggregation inhibition and antioxidant properties},
 volume = {138},
 year = {2017},
 yomi = {タグチ, リホ and ハタヤマ, コウキ and タカハシ, トモヒト and サトウ, ダイスケ and ナカノ, ヒロト and セキ, チグサ and トクラク, キヨタカ and ウワイ, コウジ}
}