{"created":"2023-06-19T10:30:03.846167+00:00","id":10210,"links":{},"metadata":{"_buckets":{"deposit":"f3a94cc5-f9d1-4ce2-9b74-f471a6b8179d"},"_deposit":{"created_by":18,"id":"10210","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"10210"},"status":"published"},"_oai":{"id":"oai:muroran-it.repo.nii.ac.jp:00010210","sets":["216:246","216:308","216:324","216:371","46"]},"author_link":["46701","46733","46731","43177","59463","47239","46732","911","57522","57517","57519"],"control_number":"10210","item_79_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-09-29","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"1075","bibliographicPageStart":"1066","bibliographicVolumeNumber":"138","bibliographic_titles":[{"bibliographic_title":"European Journal of Medicinal Chemistry","bibliographic_titleLang":"en"}]}]},"item_79_description_23":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_79_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Amyloid-β aggregation inhibitors are expected to be therapeutic or prophylactic agents for Alzheimer's disease. Rosmarinic acid, which is one of the main aggregation inhibitors derived from Lamiaceae, was employed as a lead compound and its 25 derivatives were synthesized. In this study,the structure-activity relations of rosmarinic acid derivatives for the amyloid-β aggregation inhibitory effect (MSHTS assay), antioxidant properties, and xanthine oxidase inhibition were evaluated. Among the tested compounds, compounds 16d and 19 were found to the most potent amyloid aggregation inhibitors. The SAR revealed that the necessity of the presence of the phenolic hydroxyl on one side of the molecule as well as the lipophilicity of the entire molecule. The importance of these structural properties was also supported by docking simulations.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_79_link_17":{"attribute_name":"出版者版へのリンク","attribute_value_mlt":[{"subitem_link_text":"10.1016/j.ejmech.2017.07.026","subitem_link_url":"https://doi.org/10.1016/j.ejmech.2017.07.026"}]},"item_79_link_5":{"attribute_name":"室蘭工業大学研究者データベースへのリンク","attribute_value_mlt":[{"subitem_link_text":"中野 博人（NAKANO Hiroto）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000161_ja.html"},{"subitem_link_text":"関 千草（SEKI Chigusa）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000264_ja.html"},{"subitem_link_text":"徳樂 清孝（TOKURAKU Kiyotaka）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000137_ja.html"},{"subitem_link_text":"上井 幸司（UWAI Koji）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000240_ja.html"}]},"item_79_publisher_11":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_79_relation_18":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ejmech.2017.07.026","subitem_relation_type_select":"DOI"}}]},"item_79_rights_19":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_79_source_id_12":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0223-5234","subitem_source_identifier_type":"PISSN"}]},"item_79_source_id_14":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00639621","subitem_source_identifier_type":"NCID"}]},"item_79_subject_9":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"499","subitem_subject_scheme":"NDC"}]},"item_79_version_type_21":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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