@article{oai:muroran-it.repo.nii.ac.jp:00010421, author = {CHENNAPURAM, Madhu and チェンアプラム, マデュー and OWOLABI, Isiaka Alade and オウォラビ, イシアカ アラデ and SEKI, Chigusa and 関, 千草 and OKUYAMA, Yuko and 奥山, 祐子 and KWON, Eunsang and 權, 垠相 and UWAI, Koji and 上井, 幸司 and TOKIWA, Michio and 常盤, 峻士 and TAKESHITA, Mitsuhiro and 竹下, 光弘 and 中野, 博人 and NAKANO, Hiroto}, issue = {9}, journal = {ACS OMEGA}, month = {}, note = {application/pdf, The new hybrid-type squaramide-fused amino alcohol containing both a Bronsted basic site and hydrogen bondingsites in the molecule showed a high catalytic activity as an l organocatalyst in the enantioselective domino Michael addition/cyclization reaction of oxoindohnes with cyclic 1,3-etones to afford'the chiralsproonjugate oxindoles featuring 2-aminopyrans fusing with l carbo-heterocyclic ring systems with l excellent chemical yields (up Ito 98%) and enantioselectivities (up to 95% ee). The obtained chiral spiroconjugated 2-aminopyrans bearing quaternary stereogenic carbon center could be used as l synthetic precursors for several natural products that ave a broad spectrum Iof fascinating biological activities.}, pages = {11718--11726}, title = {New Hybrid-type Squaramide-Fused Amino Alcohol Organocatalyst for Enantioselective Domino Michael Addition/Cyclization Reaction of Oxoindolines with Cyclic 1,3-Diketones}, volume = {3}, year = {2018}, yomi = {セキ, チグサ and オクヤマ, ユウコ and ウワイ, コウジ and トキワ, ミチオ and タケシタ, ミツヒロ and ナカノ, ヒロト} }