{"created":"2023-06-19T10:30:14.724780+00:00","id":10474,"links":{},"metadata":{"_buckets":{"deposit":"06d365c8-92a5-43e2-b692-7a2e44cf382d"},"_deposit":{"created_by":18,"id":"10474","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"10474"},"status":"published"},"_oai":{"id":"oai:muroran-it.repo.nii.ac.jp:00010474","sets":["216:242","46"]},"author_link":["10436","58584"],"item_79_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"3316","bibliographicPageStart":"3308","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"FOOD SCIENCE & NUTRITION","bibliographic_titleLang":"en"}]}]},"item_79_description_23":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_79_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We had previously shown that the intake of scallop mantle tissue resulted in the death of mice and rats. In this study, we investigated the liver injury caused by mantle tissue to clarify the mechanism behind its toxicity. Mantle toxin increased lipid peroxidation and decreased the reductive thiol content as well as the DPPH radical scavenging activity, catalase activity, and glutathione content in the liver of the mice. These results suggested that the mantle tissue diet caused oxidative stress through the decrease in antioxidants. In addition, mantle toxin increased the mRNA expression of endoplasmic reticulum (ER) stress- and inflammation-induced genes and the protein expression of caspase-3 and Bax (which induce apoptosis), suggesting that the mantle tissue diet causes apoptosis through oxidative stress, ER stress, and inflammation in the liver tissue. Such liver injury may be an essential cause of the rodent demise.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_79_link_17":{"attribute_name":"出版者版へのリンク","attribute_value_mlt":[{"subitem_link_text":"10.1002/fsn3.1608","subitem_link_url":"https://doi.org/10.1002/fsn3.1608"}]},"item_79_link_5":{"attribute_name":"室蘭工業大学研究者データベースへのリンク","attribute_value_mlt":[{"subitem_link_text":"長谷川 靖（HASEGAWA Yasushi）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000200_ja.html"}]},"item_79_publisher_11":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"WILEY","subitem_publisher_language":"en"}]},"item_79_relation_18":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/fsn3.1608","subitem_relation_type_select":"DOI"}}]},"item_79_rights_19":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"https://creativecommons.org/licenses/by/4.0/","subitem_rights_language":"en"}]},"item_79_source_id_12":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2048-7177","subitem_source_identifier_type":"EISSN"}]},"item_79_subject_9":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_79_version_type_21":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KARIYA, Takahide","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"HASEGAWA,  Yasushi","creatorNameLang":"en"},{"creatorName":"長谷川, 靖","creatorNameLang":"ja"},{"creatorName":"ハセガワ, ヤスシ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-06-29"}],"displaytype":"detail","filename":"FSN_2020_8_3308_3316.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FSN_2020_8_3308_3316","objectType":"fulltext","url":"https://muroran-it.repo.nii.ac.jp/record/10474/files/FSN_2020_8_3308_3316.pdf"},"version_id":"1a39d2ac-9b35-45f3-a3d2-74b7f9da6655"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"food","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"liver","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"scallop mantle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"toxin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Scallop mantle toxin induces apoptosis in liver tissues of mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Scallop mantle toxin induces apoptosis in liver tissues of mice","subitem_title_language":"en"}]},"item_type_id":"79","owner":"18","path":["46","242"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-06-29"},"publish_date":"2021-06-29","publish_status":"0","recid":"10474","relation_version_is_last":true,"title":["Scallop mantle toxin induces apoptosis in liver tissues of mice"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-10-24T08:09:56.350425+00:00"}