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アイテム
In Vivo Transcutaneous Monitoring of Hemoglobin Derivatives Using a Red-Green-Blue Camera-Based Spectral Imaging Technique
http://hdl.handle.net/10258/00010463
http://hdl.handle.net/10258/0001046358974578-e56d-4600-a07a-60a05b2e0baf
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
IntJMolSci_22_4_1528 (4.6 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article.(1) | |||||||||||||||||
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| 公開日 | 2022-03-23 | |||||||||||||||||
| 書誌情報 |
en : INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 巻 22, 号 4, p. 1528, 発行日 2021 |
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| タイトル | ||||||||||||||||||
| タイトル | In Vivo Transcutaneous Monitoring of Hemoglobin Derivatives Using a Red-Green-Blue Camera-Based Spectral Imaging Technique | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | oxygenated hemoglobin | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | deoxygenated hemoglobin | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | methemoglobin | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | tissue oxygen saturation | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | wiener estimation method | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | spectral imaging | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | multiple regression analysis | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Monte Carlo simulation | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||
| 著者 |
Khatun, Fahima
× Khatun, Fahima
× Aizu, Yoshihisa
× 相津, 佳永
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| 室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||
| 表示名 | 相津 佳永（AIZU Yoshihisa） | |||||||||||||||||
| URL | http://rdsoran.muroran-it.ac.jp/html/100000000_ja.html | |||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Cyanosis is a pathological condition that is characterized by a bluish discoloration of the skin or mucous membranes. It may result from a number of medical conditions, including disorders of the respiratory system and central nervous system, cardiovascular diseases, peripheral vascular diseases, deep vein thrombosis, and regional ischemia. Cyanosis can also be elicited from methemoglobin. Therefore, a simple, rapid, and simultaneous monitoring of changes in oxygenated hemoglobin and deoxygenated hemoglobin is useful for protective strategies against organ ischemic injury. We previously developed a red-green-blue camera-based spectral imaging method for the measurements of melanin concentration, oxygenated hemoglobin concentration (C-HbO), deoxygenated hemoglobin concentration (C-Hb(R)), total hemoglobin concentration (C-HbT) and tissue oxygen saturation (StO(2)) in skin tissues. We leveraged this approach in this study and extended it to the simultaneous quantifications of methemoglobin concentration (C-metHb), C-HbO, C-Hb(R), and StO(2). The aim of the study was to confirm the feasibility of the method to monitor C-metHb, C-HbO, C-Hb(R), C-HbT, and StO(2). We performed in vivo experiments using rat dorsal skin during methemoglobinemia induced by the administration of sodium nitrite (NaNO2) and changing the fraction of inspired oxygen (FiO(2)), including normoxia, hypoxia, and anoxia. Spectral diffuse reflectance images were estimated from an RGB image by the Wiener estimation method. Multiple regression analysis based on Monte Carlo simulations of light transport was used to estimate C-HbO, C-HbR, C-metHb, C-HbT, and StO(2). C-metHb rapidly increased with a half-maximum time of less than 30 min and reached maximal values nearly 60 min after the administration of NaNO2, whereas StO(2) dramatically dropped after the administration of NaNO2, indicating the temporary production of methemoglobin and severe hypoxemia during methemoglobinemia. Time courses of C-HbT and StO(2), while changing the FiO(2), coincided with well-known physiological responses to hyperoxia, normoxia, and hypoxia. The results indicated the potential of this method to evaluate changes in skin hemodynamics due to loss of tissue viability and vitality. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | MDPI | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 出版者版へのリンク | ||||||||||||||||||
| 表示名 | 10.3390/ijms22041528 | |||||||||||||||||
| URL | https://doi.org/10.3390/ijms22041528 | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | 10.3390/ijms22041528 | |||||||||||||||||
| 日本十進分類法 | ||||||||||||||||||
| 主題Scheme | NDC | |||||||||||||||||
| 主題 | 464 | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 権利情報 | https://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| フォーマット | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||
