| アイテムタイプ |
学術雑誌論文 / Journal Article.(1) |
| 公開日 |
2022-03-23 |
| 書誌情報 |
en : JOURNAL OF BIOMEDICAL OPTICS
巻 26,
号 3,
p. 033708,
発行日 2021
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| タイトル |
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タイトル |
Transcutaneous monitoring of hemoglobin derivatives during methemoglobinemia in rats using spectral diffuse reflectance |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
hemoglobin |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
methemoglobinemia |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
spectral imaging |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
multiple regression analysis |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Monte Carlo simulation |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Khatun, Fahima
Aizu, Yoshihisa
相津, 佳永
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| 室蘭工業大学研究者データベースへのリンク |
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表示名 |
相津 佳永（AIZU Yoshihisa） |
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URL |
http://rdsoran.muroran-it.ac.jp/html/100000000_ja.html |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Significance: Untreated methemoglobinemia may cause severe hypoxemia and even death when methemoglobin levels in the blood stream exceed 70%. Although CO-oximetry can be used to monitor the response to treatment for methemoglobinemia, it is costly and requires an invasive procedure for collecting blood samples from patients. A pulse CO-oximeter with a contact probe can be used to continuously and non-invasively measure the percentage of methemoglobin, as well as the percutaneous oxygen saturation. In terms of the prevention of infectious diseases, however, it is desirable to monitor methemoglobin and oxygen saturation levels in a non-contact manner. Diffuse reflectance spectral imaging is promising as a non-contact, non-invasive, and cost-effective clinical diagnostic tool for methemoglobinemia. Aim: To demonstrate the feasibility of visible spectral diffuse reflectance for in vivo monitoring of hemoglobin derivatives and evaluating methemoglobin production and reduction as well as hypoxemia during methemoglobinemia in rats. Approach: A new imaging approach based on the multiple regression analysis aided by Monte Carlo simulations for light transport was developed to quantify methemoglobin, oxygenated hemoglobin, and deoxygenated hemoglobin using a hyperspectral imaging system. An in vivo experiment with rats exposed to sodium nitrite (NaNO2) at different doses was performed to confirm the feasibility of the method for evaluating the dynamics of methemoglobin, oxygenated hemoglobin, and deoxygenated hemoglobin during methemoglobinemia. Systemic physiological parameters, including the percutaneous arterial oxygen saturation, heart rate (HR), and pulse distention, were measured by a commercially available pulse oximeter, and the results were compared to those obtained by the proposed method. Results: Both the methemoglobin concentration and methemoglobin saturation rapidly increased with a half-maximum time of <20 min. They reached their maximal values nearly 60 min after the administration of NaNO2. Tissue oxygen saturation dramatically dropped to a minimum of 33.7% +/- 0.4%, 23.1% +/- 5.6%, 8.8% +/- 1.7%, and 9.7% +/- 5.1% on average for NaNO2 doses of 25, 37.5, 50, and 75 mg/kg, respectively. Changes in methemoglobin concentration and tissue oxygen saturation are indicative of the temporary production of methemoglobin and severe hypoxemia during methemoglobinemia. Profound increases in the HR and pulse distention implied an elevated cardiac output caused by tachycardia and the resultant increase in peripheral blood volume to compensate for the hypoxia and hypoxemia during methemoglobinemia. This was in agreement with the time course of the peripheral hemoglobin volume concentration obtained by the proposed method. Conclusions: The proposed method is capable of the in vivo non-contact simultaneous evaluation of methemoglobin levels and hypoxemia during methemoglobinemia, and that it has potential as a tool for the diagnosis and management of methemoglobinemia. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. |
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言語 |
en |
| 出版者 |
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出版者 |
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS |
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言語 |
en |
| 出版者版へのリンク |
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表示名 |
10.1117/1.JBO.26.3.033708 |
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URL |
https://doi.org/10.1117/1.JBO.26.3.033708 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1117/1.JBO.26.3.033708 |
| 日本十進分類法 |
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主題Scheme |
NDC |
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主題 |
464 |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1083-3668 |
| 権利 |
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権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
JBO_26_3_033708 (2.9 MB)
