{"created":"2023-10-19T04:10:58.680495+00:00","id":2000094,"links":{},"metadata":{"_buckets":{"deposit":"b6edeb5d-11d5-4674-b23e-000cfc562a44"},"_deposit":{"created_by":20,"id":"2000094","owner":"20","owners":[20],"pid":{"revision_id":0,"type":"depid","value":"2000094"},"status":"published"},"_oai":{"id":"oai:muroran-it.repo.nii.ac.jp:02000094","sets":["216:246","216:308","216:324","216:371","46"]},"author_link":[],"item_79_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"116840","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry","bibliographic_titleLang":"en"}]}]},"item_79_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Amyloid β (Aβ) aggregates in the brains of patients with Alzheimer's disease (AD) and accumulates\nvia oligomerization and subsequent fiber elongation processes. These toxicity-induced neuronal\ndamage and shedding processes advance AD progression. Therefore, Aβ aggregation-inhibiting\nsubstances may contribute to the prevention and treatment of AD. We screened for Aβ42 aggregation\ninhibitory activity using various plant extracts and compounds, and found high activity for a\nGeranium thunbergii extract (EC50 = 18 μg/mL). Therefore, we screened for Aβ42 aggregation\ninhibitors among components of a G. thunbergii extract and investigated their chemical properties in\nthis study. An active substance was isolated from the ethanol extract of G. thunbergii based on the\nAβ42 aggregation inhibitory activity as an index, and the compound was identified as geraniin (1)\nbased on spectral data. However, although geraniin showed in vitro aggregation-inhibition activity,\nno binding to Aβ42 was observed via saturation transfer difference-nuclear magnetic resonance\n(STD-NMR). In contrast, the hydrolysates gallic acid (2) and corilagin (5) showed aggregationinhibiting\nactivity and binding was observed via STD-NMR. Therefore, the hydrolysates produced\nunder the conditions of the activity test may contribute to the Aβ42 aggregation-inhibition activity of\nG. thunbergii extracts. Geraniin derivatives may help prevent and treat AD.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_79_link_17":{"attribute_name":"出版者版へのリンク","attribute_value_mlt":[{"subitem_link_language":"en","subitem_link_url":"https://doi.org/10.1016/j.bmc.2022.116840"}]},"item_79_publisher_11":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_79_relation_18":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bmc.2022.116840","subitem_relation_type_select":"DOI"}}]},"item_79_rights_19":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 Elsevier Ltd","subitem_rights_language":"en"}]},"item_79_source_id_12":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0968-0896","subitem_source_identifier_type":"PISSN"}]},"item_79_version_type_21":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kubo, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Watanabe, Hikaru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kumeta, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Aizawa, Tomoyasu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"Seki, Chigusa","creatorNameLang":"en"},{"creatorName":"関, 千草","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"Nakano, Hiroto","creatorNameLang":"en"},{"creatorName":"中野, 博人","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"Tokuraku, Kiyotaka","creatorNameLang":"en"},{"creatorName":"徳樂, 清孝","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"Uwai, Koji","creatorNameLang":"en"},{"creatorName":"上井, 幸司","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-10-19"}],"displaytype":"detail","filename":"BMC2022_geranium_thunbergia_revver.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","url":{"objectType":"fulltext","url":"https://muroran-it.repo.nii.ac.jp/record/2000094/files/BMC2022_geranium_thunbergia_revver.pdf"},"version_id":"77fb3731-4c31-4219-aa91-b448fb833b8e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alzheimer’s disease,","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"amyloid-beta","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Geranium thunbergii","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"geraniin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"saturation transfer difference nuclear magnetic resonance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"amyloid β aggregation inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hydrolysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii","subitem_title_language":"en"}]},"item_type_id":"79","owner":"20","path":["46","324","246","371","308"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-28"},"publish_date":"2024-05-28","publish_status":"0","recid":"2000094","relation_version_is_last":true,"title":["Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii"],"weko_creator_id":"20","weko_shared_id":-1},"updated":"2023-10-19T04:46:54.185671+00:00"}