@article{oai:muroran-it.repo.nii.ac.jp:00007072, author = {HIRAMA, Masafumi and KATO, Yuji and SEKI, Chigusa and 関, 千草 and 中野, 博人 and NAKANO, Hiroto and TAKESHITA, Mitsuhiro and 竹下, 光弘 and OSHIKIRI, Noriko and IYODA, Masahiko and 松山, 春男 and MATSUYAMA, Haruo}, issue = {38}, journal = {Tetrahedron}, month = {Sep}, note = {application/pdf, The Diels-Alder reaction of 1,2-dihydropyridine derivatives (1-phenoxycarbonyl-1,2-dihydropyridine 1 or 1-methoxycarbonyl-1,2-dihydropyridine 4) with N-acryloyl (1S)-2,10-camphorsultam (1S)-2 (or N-acryloyl (1R)-2,10-camphorsultam (1R)-2) in the presence of Lewisacid such as titanium tetrachloride, zirconium tetrachloride, and hafnium tetrachloride afforded the endo-cycloaddition product, 2-azabicyclo[2.2.2]octane derivatives in good yields with excellent diastereoselectivity. The absolute stereochemistry assignment of the endo-cycloaddition product (1S)-5a starting from N-acryloyl (1S)-2,10-camphorsultam (1S)-2hasbeen established to be (1S, 4R, 7S) and the reaction mechanism was proposed.}, pages = {7618--7624}, title = {An efficient synthesis of chiral isoquinuclidines by Diels-Alder reaction using Lewis acid catalyst}, volume = {66}, year = {2010}, yomi = {セキ, チグサ and ナカノ, ヒロト and タケシタ, ミツヒロ and マツヤマ, ハルオ} }