@inproceedings{oai:muroran-it.repo.nii.ac.jp:00008628,
 author = {田口, 莉帆 and TAGUCHI, Riho and 高橋, 倫人 and TAKAHASHI, Tomohito and 畑山, 晃輝 and HATAYAMA, Koki and 橋, 友理香 and HASHI, Yurika and SEKI,  Chigusa and 関, 千草 and 中野, 博人 and NAKANO, Hiroto and TOKURAKU, Kiyotaka and 徳樂, 清孝 and Uwai,  Koji and 上井, 幸司},
 book = {メディシナルケミストリーシンポジウム講演要旨集, Symposium on Medicinal Chemistry},
 month = {Nov},
 note = {application/pdf, As the aggregation of Αβ peptide has been considered as one of the pathogenesis of Alzheimer's disease, development of the potent inhibitor has been required for its complete recovery. We have identified rosmarinic acid with a major Αβ aggregation inhibitor of summer savory, one of the member of Lamiaceae. Therefore, we designed several rosmarinic acid derivatives for anti-Αβ aggregation drug candidates. Anti-Αβ aggregation activity was evaluated by our developed method “micro littlers scale high-throughput screening (MSHTS) system”. The results showed the presence of the phenol hydroxyl group and hydrophobic alkoxy group is very important for the activity. The docking study between Αβ42 and synthesized compounds and their ThT assays are ongoing. The details of SAR studies of rosmarinic acid derivatives with Αβ42 will be presented., 2P-13},
 pages = {147--147},
 publisher = {日本薬学会医薬化学部会},
 title = {ロスマリン酸誘導体のAβ凝集阻害活性とその構造活性相関},
 volume = {33},
 year = {2015},
 yomi = {タグチ, リホ and タカハシ, トモヒト and ハタヤマ, コウキ and ハシ, ユリカ and セキ, チグサ and ナカノ, ヒロト and トクラク, キヨタカ and ウワイ, コウジ}
}