{"created":"2023-06-19T10:28:59.760568+00:00","id":8628,"links":{},"metadata":{"_buckets":{"deposit":"9ba2f987-3e66-4008-ac2a-9b961096cb2b"},"_deposit":{"created_by":18,"id":"8628","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8628"},"status":"published"},"_oai":{"id":"oai:muroran-it.repo.nii.ac.jp:00008628","sets":["216:246","216:308","216:324","216:371","48"]},"author_link":["46701","46733","46731","43177","46734","46732","59463","911"],"item_1694052902339":{"attribute_name":"会議記述","attribute_value_mlt":[{"subitem_conference_names":[{"subitem_conference_name":"メディシナルケミストリーシンポジウム","subitem_conference_name_language":"ja"}]}]},"item_82_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"147","bibliographicPageStart":"147","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"メディシナルケミストリーシンポジウム講演要旨集","bibliographic_titleLang":"ja"},{"bibliographic_title":"Symposium on Medicinal Chemistry","bibliographic_titleLang":"en"}]}]},"item_82_description_23":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_82_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"As the aggregation of Αβ peptide has been considered as one of the pathogenesis of Alzheimer's disease, development of the potent inhibitor has been required for its complete recovery. We have identified rosmarinic acid with a major Αβ aggregation inhibitor of summer savory, one of the member of Lamiaceae. Therefore, we designed several rosmarinic acid derivatives for anti-Αβ aggregation drug candidates. Anti-Αβ aggregation activity was evaluated by our developed method “micro littlers scale high-throughput screening (MSHTS) system”. The results showed the presence of the phenol hydroxyl group and hydrophobic alkoxy group is very important for the activity. The docking study between Αβ42 and synthesized compounds and their ThT assays are ongoing. The details of SAR studies of rosmarinic acid derivatives with Αβ42 will be presented.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_82_description_8":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"2P-13","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_82_link_5":{"attribute_name":"室蘭工業大学研究者データベースへのリンク","attribute_value_mlt":[{"subitem_link_text":"関 千草（SEKI Chigusa）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000264_ja.html"},{"subitem_link_text":"中野 博人（NAKANO Hiroto）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000161_ja.html"},{"subitem_link_text":"徳樂 清孝（TOKURAKU Kiyotaka）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000137_ja.html"},{"subitem_link_text":"上井 幸司（UWAI Koji）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000240_ja.html"}]},"item_82_publisher_11":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会医薬化学部会","subitem_publisher_language":"ja"}]},"item_82_rights_19":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2015 日本薬学会医薬化学部会","subitem_rights_language":"ja"}]},"item_82_source_id_12":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0919-214X","subitem_source_identifier_type":"PISSN"}]},"item_82_source_id_14":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1208032X","subitem_source_identifier_type":"NCID"}]},"item_82_subject_9":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"499","subitem_subject_scheme":"NDC"}]},"item_82_version_type_21":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"田口, 莉帆","creatorNameLang":"ja"},{"creatorName":"TAGUCHI, Riho","creatorNameLang":"en"},{"creatorName":"タグチ, リホ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"高橋, 倫人","creatorNameLang":"ja"},{"creatorName":"TAKAHASHI, Tomohito","creatorNameLang":"en"},{"creatorName":"タカハシ, トモヒト","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"畑山, 晃輝","creatorNameLang":"ja"},{"creatorName":"HATAYAMA, Koki","creatorNameLang":"en"},{"creatorName":"ハタヤマ, コウキ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"橋, 友理香","creatorNameLang":"ja"},{"creatorName":"HASHI, Yurika","creatorNameLang":"en"},{"creatorName":"ハシ, ユリカ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"SEKI,  Chigusa","creatorNameLang":"en"},{"creatorName":"関, 千草","creatorNameLang":"ja"},{"creatorName":"セキ, チグサ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"中野, 博人","creatorNameLang":"ja"},{"creatorName":"NAKANO, Hiroto","creatorNameLang":"en"},{"creatorName":"ナカノ, ヒロト","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"TOKURAKU, Kiyotaka","creatorNameLang":"en"},{"creatorName":"トクラク, キヨタカ","creatorNameLang":"ja-Kana"},{"creatorName":"徳樂, 清孝","creatorNameLang":"ja"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"Uwai,  Koji","creatorNameLang":"en"},{"creatorName":"上井, 幸司","creatorNameLang":"ja"},{"creatorName":"ウワイ, コウジ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-07"}],"displaytype":"detail","filename":"33_147.pdf","filesize":[{"value":"710.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"33_147.pdf","objectType":"abstract","url":"https://muroran-it.repo.nii.ac.jp/record/8628/files/33_147.pdf"},"version_id":"1766f2a6-ee5c-4f97-b178-a3f5bc8bba12"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"ロスマリン酸誘導体のAβ凝集阻害活性とその構造活性相関","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ロスマリン酸誘導体のAβ凝集阻害活性とその構造活性相関","subitem_title_language":"ja"},{"subitem_title":"Inhibitory effect of amyloid-beta aggregation on rosmarinic acid derivatives and their structure-activity relationship","subitem_title_language":"en"}]},"item_type_id":"82","owner":"18","path":["48","324","308","246","371"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-04-07"},"publish_date":"2016-04-07","publish_status":"0","recid":"8628","relation_version_is_last":true,"title":["ロスマリン酸誘導体のAβ凝集阻害活性とその構造活性相関"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-10T02:51:36.787031+00:00"}