{"created":"2023-06-19T10:28:59.848192+00:00","id":8630,"links":{},"metadata":{"_buckets":{"deposit":"a24541b7-18ba-441e-a979-2bec55645bac"},"_deposit":{"created_by":18,"id":"8630","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8630"},"status":"published"},"_oai":{"id":"oai:muroran-it.repo.nii.ac.jp:00008630","sets":["216:246","216:308","216:324","48"]},"author_link":["43177","46721","59463","46719","46722","911"],"item_1694052902339":{"attribute_name":"会議記述","attribute_value_mlt":[{"subitem_conference_names":[{"subitem_conference_name":"メディシナルケミストリーシンポジウム","subitem_conference_name_language":"ja"}]}]},"item_82_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"148","bibliographicPageStart":"148","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"メディシナルケミストリーシンポジウム講演要旨集","bibliographic_titleLang":"ja"},{"bibliographic_title":"Symposium on Medicinal Chemistry","bibliographic_titleLang":"en"}]}]},"item_82_description_23":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_82_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tamiflu is a potent inhibitory neuraminidase that is used worldwide as a drug for influenza. However, most recently, a microbe resistant to Tamiflu was confirmed. Therefore, the development of an effective new anti-influenza molecules is needed as soon as possible. In this study, we tried to prepare a new antiviral candidate molecules having the characteristic of both Tamiflu and Relenza by using amino alcohol organocatalyzed DA reaction of 1,2-dihydropyridines with acrolein as a key reaction. We will describe that the synthesis of both the key intermediates 5 and 6 that were obtained from the chiral isoquinuclidine deriveative 3, and the preparation of new antiviral candidate molecules X, Y derived from 5, 6 and its anti-influenza activety.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_82_description_8":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"2P-14","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_82_link_5":{"attribute_name":"室蘭工業大学研究者データベースへのリンク","attribute_value_mlt":[{"subitem_link_text":"関 千草（SEKI Chigusa）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000264_ja.html"},{"subitem_link_text":"上井 幸司（UWAI Koji）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000240_ja.html"},{"subitem_link_text":"中野 博人（NAKANO Hiroto）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000161_ja.html"}]},"item_82_publisher_11":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会医薬化学部会","subitem_publisher_language":"ja"}]},"item_82_rights_19":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2015 日本薬学会医薬化学部会","subitem_rights_language":"ja"}]},"item_82_source_id_12":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0919-214X","subitem_source_identifier_type":"PISSN"}]},"item_82_source_id_14":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1208032X","subitem_source_identifier_type":"NCID"}]},"item_82_subject_9":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"499","subitem_subject_scheme":"NDC"}]},"item_82_version_type_21":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高木, 僚平","creatorNameLang":"ja"},{"creatorName":"TAKAGI, Ryohei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"SEKI,  Chigusa","creatorNameLang":"en"},{"creatorName":"関, 千草","creatorNameLang":"ja"},{"creatorName":"セキ, チグサ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小川, 晴子","creatorNameLang":"ja"},{"creatorName":"OGAWA, Haruko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今井, 邦俊","creatorNameLang":"ja"},{"creatorName":"IMAI, Kunitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"Uwai,  Koji","creatorNameLang":"en"},{"creatorName":"上井, 幸司","creatorNameLang":"ja"},{"creatorName":"ウワイ, コウジ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"中野, 博人","creatorNameLang":"ja"},{"creatorName":"NAKANO, Hiroto","creatorNameLang":"en"},{"creatorName":"ナカノ, ヒロト","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-07"}],"displaytype":"detail","filename":"33_148.pdf","filesize":[{"value":"719.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"33_148.pdf","objectType":"abstract","url":"https://muroran-it.repo.nii.ac.jp/record/8630/files/33_148.pdf"},"version_id":"067af251-a1fc-4a66-a120-f19d10c89a5d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"アミノアルコール有機分子触媒不斉Diels‐Alder反応を鍵反応とする新規抗インフルエンザ活性物質の合成研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アミノアルコール有機分子触媒不斉Diels‐Alder反応を鍵反応とする新規抗インフルエンザ活性物質の合成研究","subitem_title_language":"ja"},{"subitem_title":"Development or new anti-influenza molecules using organocatalyzed Diels-Alder reaction of 1,2-dihydropyridines with dienophiles as a key reaction","subitem_title_language":"en"}]},"item_type_id":"82","owner":"18","path":["48","324","308","246"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-04-07"},"publish_date":"2016-04-07","publish_status":"0","recid":"8630","relation_version_is_last":true,"title":["アミノアルコール有機分子触媒不斉Diels‐Alder反応を鍵反応とする新規抗インフルエンザ活性物質の合成研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-10-24T02:39:46.756900+00:00"}