@article{oai:muroran-it.repo.nii.ac.jp:00009210,
 author = {門田, 有起也 and KADOTA, Yukiya and 中川, 絵利奈 and NAKAGAWA, Erina and 川南, 諭 and KAWAMINAMI, Satoshi and HASEGAWA,  Yasushi and 長谷川, 靖},
 journal = {室蘭工業大学紀要, Memoirs of the Muroran Institute of Technology},
 month = {Mar},
 note = {application/pdf, Lignosulfonic acid is a waste lignin produced from the sulfite pulping of softwood. We investigated the effect of lignosulfonic acid on α-glucosidase and found that lignosulfonic acid produced a reversible and non-competitive inhibition of the enzyme activity. Moreover, in human colorectal adenocarcinoma cells, lignosulfonic acid inhibited 2-deoxyglucose uptake, while in vivo studies demonstrated a significant reduction in the blood glycemic response to sucrose or glucose ingestion in rats treated with lignosulfonic acid. Feces of rats fed a diet supplemented with 5% lignosulfonic acid had higher sugar content compared to those of rats fed a control diet. These results suggest that lignosulfonic acid suppresses the rise in blood glucose levels through inhibition of α-glucosidase activity and intestinal glucose absorption. Additionally, lignosulfonic acid suppressed increase of blood glucose level in diabetic KK-Ay mice. These results suggest that lignosulfonic acid may be useful as an anti-diabetes agent., 特集},
 pages = {11--15},
 title = {リグニンスルホン酸による食後高血糖抑制作用},
 volume = {66},
 year = {2017},
 yomi = {カドタ, ユキヤ and ナカガワ, エリナ and カワミナミ, サトシ and ハセガワ, ヤスシ}
}