{"created":"2023-06-19T10:29:23.090099+00:00","id":9210,"links":{},"metadata":{"_buckets":{"deposit":"b5d21fec-55ad-486a-8e76-e4917521ad7e"},"_deposit":{"created_by":18,"id":"9210","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"9210"},"status":"published"},"_oai":{"id":"oai:muroran-it.repo.nii.ac.jp:00009210","sets":["216:242","35:426"]},"author_link":["10436","54237","54239","54238"],"item_77_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-24","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"15","bibliographicPageStart":"11","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"室蘭工業大学紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Memoirs of the Muroran Institute of Technology","bibliographic_titleLang":"en"}]}]},"item_77_description_23":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_77_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lignosulfonic acid is a waste lignin produced from the sulfite pulping of softwood. We investigated the effect of lignosulfonic acid on α-glucosidase and found that lignosulfonic acid produced a reversible and non-competitive inhibition of the enzyme activity. Moreover, in human colorectal adenocarcinoma cells, lignosulfonic acid inhibited 2-deoxyglucose uptake, while in vivo studies demonstrated a significant reduction in the blood glycemic response to sucrose or glucose ingestion in rats treated with lignosulfonic acid. Feces of rats fed a diet supplemented with 5% lignosulfonic acid had higher sugar content compared to those of rats fed a control diet. These results suggest that lignosulfonic acid suppresses the rise in blood glucose levels through inhibition of α-glucosidase activity and intestinal glucose absorption. Additionally, lignosulfonic acid suppressed increase of blood glucose level in diabetic KK-Ay mice. These results suggest that lignosulfonic acid may be useful as an anti-diabetes agent.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_77_description_8":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_77_link_5":{"attribute_name":"室蘭工業大学研究者データベースへのリンク","attribute_value_mlt":[{"subitem_link_text":"長谷川 靖（HASEGAWA Yasushi）","subitem_link_url":"http://rdsoran.muroran-it.ac.jp/html/100000200_ja.html"}]},"item_77_publisher_11":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"室蘭工業大学","subitem_publisher_language":"ja"}]},"item_77_rights_19":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 室蘭工業大学","subitem_rights_language":"ja"}]},"item_77_source_id_12":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13442708","subitem_source_identifier_type":"PISSN"}]},"item_77_source_id_14":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11912609","subitem_source_identifier_type":"NCID"}]},"item_77_subject_9":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.123","subitem_subject_scheme":"NDC"}]},"item_77_version_type_21":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"門田, 有起也","creatorNameLang":"ja"},{"creatorName":"KADOTA, Yukiya","creatorNameLang":"en"},{"creatorName":"カドタ, ユキヤ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"中川, 絵利奈","creatorNameLang":"ja"},{"creatorName":"NAKAGAWA, Erina","creatorNameLang":"en"},{"creatorName":"ナカガワ, エリナ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"川南, 諭","creatorNameLang":"ja"},{"creatorName":"KAWAMINAMI, Satoshi","creatorNameLang":"en"},{"creatorName":"カワミナミ, サトシ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{},{}]}],"creatorNames":[{"creatorName":"HASEGAWA,  Yasushi","creatorNameLang":"en"},{"creatorName":"長谷川, 靖","creatorNameLang":"ja"},{"creatorName":"ハセガワ, ヤスシ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-24"}],"displaytype":"detail","filename":"66_11.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"66_11.pdf","objectType":"fulltext","url":"https://muroran-it.repo.nii.ac.jp/record/9210/files/66_11.pdf"},"version_id":"923dbf4b-1c97-44d5-b7a9-6b0a5b3e2b19"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lignin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α-glucosidase","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"リグニンスルホン酸による食後高血糖抑制作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"リグニンスルホン酸による食後高血糖抑制作用","subitem_title_language":"ja"},{"subitem_title":"Lignosulfonic acid suppresses postprandial hyperglycemia","subitem_title_language":"en"}]},"item_type_id":"77","owner":"18","path":["426","242"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-03-23"},"publish_date":"2017-03-23","publish_status":"0","recid":"9210","relation_version_is_last":true,"title":["リグニンスルホン酸による食後高血糖抑制作用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-25T06:25:48.620576+00:00"}