The ractions between the detectable substance and the molecular recognition element could be detected using the devices converting physical quantity to an electric signal. In this case, electric charge as a sensing signal can be detected using field effect transistor (FET) configuration. In contrast, optical sensing devices can detect light intensity change using a photomultiplier. As an another approach, quartz crystal microbalance (QCM) and surface acoustic wave (SAW) sensors in both have been used for an element detecting the mass change. A QCM sensor using a bulk wave traveling through the interior of the piezoelectric element is already commercialized with the operation frequency with 5 to 30 MHz depending on the quartz thickness. In contrast, a SAW is caused to occur by applying a high frequency to the interdigital transducer (IDT) electrode disposed on the piezoelectric surface. Operating frequency depends on the IDT width and can easily generate frequencies in the MHz band by semiconductor processing technology. A mass change of the solution occurs in the signal with highly sensitive operation, thereby solution sensor of the SAW method has been expected. The purpose of this study is to produce a liquid phase system sensor using a longitudinal wave radiation into a liquid phase by Rayleigh wave, which is one of the SAW mode. To clarify what is a parameter in the liquid based on the establishment of basic theory we have performed series of measurements The sensor using a longitudinal wave radiation of dozens MHz band had been investigated. In our device, there is several problems in which liquid leaks from the gap of the cell for fixing the liquid and attenuation of the signal. We have solved the structural problem by using glass groove holder provided with hydrophilic and water repelling area and enabled to measure at a high frequency of 150～200 MHz We proposed longitudinal wave radiation model. Lab-on-a-chip, called the ultimate biochip, is the device that the reactions and changes of the protein detects and analyzes instantly. Rayleigh type SAW sensor using a grooved holder is supposed to be used on a lab-on-a-chip, we report on the research results from the measurements of the protein concentration as an antibody and Adenosine of the energy metabolites of biological and so on.
縦波放射を利用したレイリー型表面弾性波の液相系センサーの開発とバイオセンシングシステムへの応用に関する研究
A377_summary.pdf
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