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アミノアルコール有機分子触媒不斉Diels‐Alder反応を鍵反応とする新規抗インフルエンザ活性物質の合成研究
http://hdl.handle.net/10258/00008620
http://hdl.handle.net/10258/00008620e2bb69e9-8599-438b-b51f-9e57682dce98
名前 / ファイル | ライセンス | アクション |
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33_148.pdf (719.8 kB)
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Item type | 会議発表論文 / Conference Paper(1) | |||||||||||||||||||||||
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公開日 | 2016-04-07 | |||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||
タイトル | アミノアルコール有機分子触媒不斉Diels‐Alder反応を鍵反応とする新規抗インフルエンザ活性物質の合成研究 | |||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
タイトル | Development or new anti-influenza molecules using organocatalyzed Diels-Alder reaction of 1,2-dihydropyridines with dienophiles as a key reaction | |||||||||||||||||||||||
言語 | ||||||||||||||||||||||||
言語 | jpn | |||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||||||||||||||||||||
資源タイプ | conference paper | |||||||||||||||||||||||
アクセス権 | ||||||||||||||||||||||||
アクセス権 | open access | |||||||||||||||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||
著者 |
高木, 僚平
× 高木, 僚平× 関, 千草
WEKO
43177
× 小川, 晴子× 今井, 邦俊× 上井, 幸司
WEKO
911
× 中野, 博人
WEKO
59463
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室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||
関 千草(SEKI Chigusa) | ||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000264_ja.html | ||||||||||||||||||||||||
室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||
上井 幸司(UWAI Koji) | ||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000240_ja.html | ||||||||||||||||||||||||
室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||
中野 博人(NAKANO Hiroto) | ||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000161_ja.html | ||||||||||||||||||||||||
抄録 | ||||||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||||||
内容記述 | Tamiflu is a potent inhibitory neuraminidase that is used worldwide as a drug for influenza. However, most recently, a microbe resistant to Tamiflu was confirmed. Therefore, the development of an effective new anti-influenza molecules is needed as soon as possible. In this study, we tried to prepare a new antiviral candidate molecules having the characteristic of both Tamiflu and Relenza by using amino alcohol organocatalyzed DA reaction of 1,2-dihydropyridines with acrolein as a key reaction. We will describe that the synthesis of both the key intermediates 5 and 6 that were obtained from the chiral isoquinuclidine deriveative 3, and the preparation of new antiviral candidate molecules X, Y derived from 5, 6 and its anti-influenza activety. | |||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
書誌情報 |
ja : メディシナルケミストリーシンポジウム講演要旨集 en : Symposium on Medicinal Chemistry 巻 33, p. 148-148, 発行日 2015-11-01 |
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会議記述 | ||||||||||||||||||||||||
会議名 | メディシナルケミストリーシンポジウム | |||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||
注記 | ||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||
内容記述 | 2P-14 | |||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
出版者 | ||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||
出版者 | 日本薬学会医薬化学部会 | |||||||||||||||||||||||
日本十進分類法 | ||||||||||||||||||||||||
主題Scheme | NDC | |||||||||||||||||||||||
主題 | 499 | |||||||||||||||||||||||
ISSN | ||||||||||||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||||||||||||
収録物識別子 | 0919-214X | |||||||||||||||||||||||
書誌レコードID | ||||||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||||||
収録物識別子 | AA1208032X | |||||||||||||||||||||||
権利 | ||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||
権利情報 | © 2015 日本薬学会医薬化学部会 | |||||||||||||||||||||||
著者版フラグ | ||||||||||||||||||||||||
出版タイプ | VoR | |||||||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
フォーマット | ||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||
内容記述 | application/pdf |