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Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and Aβ Aggregation
http://hdl.handle.net/10258/00010314
http://hdl.handle.net/10258/000103147566d656-b29a-4d56-863e-40fbe066e687
名前 / ファイル | ライセンス | アクション |
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MICL_2020_25_18_4077 (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article.(1) | |||||||||||||||||||||||
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公開日 | 2020-11-16 | |||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
タイトル | Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and Aβ Aggregation | |||||||||||||||||||||||
言語 | ||||||||||||||||||||||||
言語 | eng | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | daurichromenic acid | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | sphingomyelin synthase | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | amyloid β | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | dual inhibitor | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | lipid-related disease | |||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
資源タイプ | journal article | |||||||||||||||||||||||
アクセス権 | ||||||||||||||||||||||||
アクセス権 | open access | |||||||||||||||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||
著者 |
HADAY, Virupaksha Deepak
× HADAY, Virupaksha Deepak× MAHADEVA, M. M. Swamy× MURAI, Yuta× SUGA, Yoshiko× ANETAI, Masaki× YO, Takuro× 倉賀野, 正弘
WEKO
57048
× 上井, 幸司
WEKO
911
× 徳樂, 清孝
WEKO
46701
× MONDE, Kenji |
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室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||
上井 幸司(UWAI Koji) | ||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000240_ja.html | ||||||||||||||||||||||||
室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||
徳樂 清孝(TOKURAKU Kiyotaka) | ||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000137_ja.html | ||||||||||||||||||||||||
抄録 | ||||||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||||||
内容記述 | Species of the genus Rhododendron have been used in traditional Chinese medicine, with the medicinal herb “Manshanfong” used as an expectorant and for the treatment of acute bronchitis. Daurichromenic acid (DCA), a constituent of Rhododendron dauricum, is a meroterpenoid with antibacterial, anti-HIV, and anti-inflammatory activities. However, the mechanisms underlying these pharmacologic activities are poorly understood. To develop new drugs based on DCA, more information is required regarding its interactions with biomolecules. The present study showed that DCA inhibits the activity of the enzyme sphingomyelin synthase, with an IC50 of 4 µM. The structure–activity relationships between DCA and sphingomyelin synthase were evaluated using derivatives and cyclized hongoquercin A. In addition, DCA was found to inhibit amyloid β aggregation. These results may help in the design of effective drugs based on DCA. | |||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
書誌情報 |
en : Molecules 巻 25, 号 18, 発行日 2020 |
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出版者 | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
出版者 | MDPI | |||||||||||||||||||||||
出版者版へのリンク | ||||||||||||||||||||||||
10.3390/molecules25184077 | ||||||||||||||||||||||||
https://doi.org/10.3390/molecules25184077 | ||||||||||||||||||||||||
DOI | ||||||||||||||||||||||||
関連タイプ | isIdenticalTo | |||||||||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||||||||
関連識別子 | 10.3390/molecules25184077 | |||||||||||||||||||||||
日本十進分類法 | ||||||||||||||||||||||||
主題Scheme | NDC | |||||||||||||||||||||||
主題 | 499 | |||||||||||||||||||||||
ISSN | ||||||||||||||||||||||||
収録物識別子タイプ | EISSN | |||||||||||||||||||||||
収録物識別子 | 1420-3049 | |||||||||||||||||||||||
権利 | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
権利情報 | ©2020 by the authors; licensee MDPI AG, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution License(http://creativecommons.org/licenses/by/4.0/) | |||||||||||||||||||||||
著者版フラグ | ||||||||||||||||||||||||
出版タイプ | VoR | |||||||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
フォーマット | ||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||
内容記述 | application/pdf |