| Item type |
学術雑誌論文 / Journal Article.(1) |
| 公開日 |
2021-06-29 |
| 書誌情報 |
en : INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
巻 21,
号 17,
発行日 2020
|
| タイトル |
|
|
タイトル |
Dietary Intake of Rosmarinic Acid Increases Serum Inhibitory Activity in Amyloid A Aggregation and Suppresses Deposition in the Organs of Mice |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Amyloid A amyloidosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
serum amyloid A |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
amyloid beta |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Melissa officinalis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
microliter-scale high-throughput screening system |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
rosmarinic acid |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
リン, シュウグアン
WATANABE, Kenichi
倉賀野, 正弘
KUROTAKI, Yukina
NAKANISHI, Ushio
徳樂, 清孝
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| 室蘭工業大学研究者データベースへのリンク |
|
|
表示名 |
徳樂 清孝（TOKURAKU Kiyotaka） |
|
URL |
http://rdsoran.muroran-it.ac.jp/html/100000137_ja.html |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Serum amyloid A (SAA) is one of the most important precursor amyloid proteins and plays a vital step in AA amyloidosis, although the underlying aggregation mechanism has not been elucidated. Since SAA aggregation is a key step in this pathogenesis, inhibitors are useful to prevent and treat AA amyloidosis, serving as tools to investigate the pathogenic mechanism. In this study, we showed that rosmarinic acid (RA), which is a well-known inhibitor of the aggregation of amyloid beta (A beta), displayed inhibitory activity against SAA aggregation in vitro using a microliter-scale high-throughput screening (MSHTS) system with quantum-dot nanoprobes. Therefore, we evaluated the amyloid aggregation inhibitory activity of blood and the deposition of SAA in organs by feeding mice withMelissa officinalisextract (ME) containing RA as an active substance. Interestingly, the inhibitory activity of ME-fed mice sera for SAA and A beta aggregation, measured with the MSHTS system, was higher than that of the control group. The amount of amyloid deposition in the organs of ME-fed mice was lower than that in the control group, suggesting that the SAA aggregation inhibitory activity of serum is associated with SAA deposition. These results suggest that dietary intake of RA-containing ME enhanced amyloid aggregation inhibitory activity of blood and suppressed SAA deposition in organs. This study also demonstrated that the MSHTS system could be applied to in vitro screening and to monitor comprehensive activity of metabolized foods adsorbed by blood. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 出版者版へのリンク |
|
|
表示名 |
10.3390/ijms21176031 |
|
URL |
https://doi.org/10.3390/ijms21176031 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.3390/ijms21176031 |
| 日本十進分類法 |
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|
主題Scheme |
NDC |
|
主題 |
499 |
| 権利 |
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|
言語 |
en |
|
権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
IJMS_2020_21_6031 (2.6 MB)
