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Structure-activity relations of rosmarinic acid derivatives for the amyloid β aggregation inhibition and antioxidant properties
http://hdl.handle.net/10258/00010157
http://hdl.handle.net/10258/00010157e3f0e7bc-7f60-41ae-ad40-10d41f1a8fdb
名前 / ファイル | ライセンス | アクション |
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EJMC_138_1066_1075 (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article.(1) | |||||||||||||||||||||||||||||||
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公開日 | 2020-03-12 | |||||||||||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
タイトル | Structure-activity relations of rosmarinic acid derivatives for the amyloid β aggregation inhibition and antioxidant properties | |||||||||||||||||||||||||||||||
言語 | ||||||||||||||||||||||||||||||||
言語 | eng | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | Alzheimer's disease | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | structure-activity relationship | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | inhibitor | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | rosmarinic acid | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | amyloid-beta | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | aggregation | |||||||||||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||
資源タイプ | journal article | |||||||||||||||||||||||||||||||
アクセス権 | ||||||||||||||||||||||||||||||||
アクセス権 | open access | |||||||||||||||||||||||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||||||||
著者 |
田口, 莉帆
× 田口, 莉帆× 畑山, 晃輝× 高橋, 倫人× HAYASHI, Takafumi
× SATO, Yuki× 佐藤, 大輔× OTA, Kiminori× 中野, 博人
WEKO
59463
× 関, 千草
WEKO
43177
× ENDO, Yasuyuki× 徳樂, 清孝
WEKO
46701
× 上井, 幸司
WEKO
911
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室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||||||||||
中野 博人(NAKANO Hiroto) | ||||||||||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000161_ja.html | ||||||||||||||||||||||||||||||||
室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||||||||||
関 千草(SEKI Chigusa) | ||||||||||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000264_ja.html | ||||||||||||||||||||||||||||||||
室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||||||||||
徳樂 清孝(TOKURAKU Kiyotaka) | ||||||||||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000137_ja.html | ||||||||||||||||||||||||||||||||
室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||||||||||
上井 幸司(UWAI Koji) | ||||||||||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000240_ja.html | ||||||||||||||||||||||||||||||||
抄録 | ||||||||||||||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||||||||||||||
内容記述 | Amyloid-β aggregation inhibitors are expected to be therapeutic or prophylactic agents for Alzheimer's disease. Rosmarinic acid, which is one of the main aggregation inhibitors derived from Lamiaceae, was employed as a lead compound and its 25 derivatives were synthesized. In this study,the structure-activity relations of rosmarinic acid derivatives for the amyloid-β aggregation inhibitory effect (MSHTS assay), antioxidant properties, and xanthine oxidase inhibition were evaluated. Among the tested compounds, compounds 16d and 19 were found to the most potent amyloid aggregation inhibitors. The SAR revealed that the necessity of the presence of the phenolic hydroxyl on one side of the molecule as well as the lipophilicity of the entire molecule. The importance of these structural properties was also supported by docking simulations. | |||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
書誌情報 |
en : European Journal of Medicinal Chemistry 巻 138, p. 1066-1075, 発行日 2017-09-29 |
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出版者 | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
出版者 | Elsevier | |||||||||||||||||||||||||||||||
出版者版へのリンク | ||||||||||||||||||||||||||||||||
10.1016/j.ejmech.2017.07.026 | ||||||||||||||||||||||||||||||||
https://doi.org/10.1016/j.ejmech.2017.07.026 | ||||||||||||||||||||||||||||||||
DOI | ||||||||||||||||||||||||||||||||
関連タイプ | isVersionOf | |||||||||||||||||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||||||||||||||||
関連識別子 | 10.1016/j.ejmech.2017.07.026 | |||||||||||||||||||||||||||||||
日本十進分類法 | ||||||||||||||||||||||||||||||||
主題Scheme | NDC | |||||||||||||||||||||||||||||||
主題 | 499 | |||||||||||||||||||||||||||||||
ISSN | ||||||||||||||||||||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||||||||||||||||||||
収録物識別子 | 0223-5234 | |||||||||||||||||||||||||||||||
書誌レコードID | ||||||||||||||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||||||||||||||
収録物識別子 | AA00639621 | |||||||||||||||||||||||||||||||
権利 | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
権利情報 | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||||||||||||||
著者版フラグ | ||||||||||||||||||||||||||||||||
出版タイプ | AM | |||||||||||||||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||||||||||
フォーマット | ||||||||||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||||||||||
内容記述 | application/pdf |