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Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii
http://hdl.handle.net/10258/0002000094
http://hdl.handle.net/10258/00020000941e5b0cc7-c7a4-4396-ae39-d59cee38f936
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article.(1) | |||||||||||||||||||||||||||||
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公開日 | 2024-05-28 | |||||||||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
タイトル | Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii | |||||||||||||||||||||||||||||
言語 | ||||||||||||||||||||||||||||||
言語 | eng | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | Alzheimer’s disease, | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | amyloid-beta | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | Geranium thunbergii | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | geraniin | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | saturation transfer difference nuclear magnetic resonance | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | amyloid β aggregation inhibitor | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | hydrolysis | |||||||||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||
資源タイプ | journal article | |||||||||||||||||||||||||||||
アクセス権 | ||||||||||||||||||||||||||||||
アクセス権 | open access | |||||||||||||||||||||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||||||
著者 |
Kubo, Kenji
× Kubo, Kenji
× Watanabe, Hikaru
× Kumeta, Hiroyuki
× Aizawa, Tomoyasu
× 関, 千草
× 中野, 博人
× 徳樂, 清孝
× 上井, 幸司
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抄録 | ||||||||||||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||||||||||||
内容記述 | Amyloid β (Aβ) aggregates in the brains of patients with Alzheimer's disease (AD) and accumulates via oligomerization and subsequent fiber elongation processes. These toxicity-induced neuronal damage and shedding processes advance AD progression. Therefore, Aβ aggregation-inhibiting substances may contribute to the prevention and treatment of AD. We screened for Aβ42 aggregation inhibitory activity using various plant extracts and compounds, and found high activity for a Geranium thunbergii extract (EC50 = 18 μg/mL). Therefore, we screened for Aβ42 aggregation inhibitors among components of a G. thunbergii extract and investigated their chemical properties in this study. An active substance was isolated from the ethanol extract of G. thunbergii based on the Aβ42 aggregation inhibitory activity as an index, and the compound was identified as geraniin (1) based on spectral data. However, although geraniin showed in vitro aggregation-inhibition activity, no binding to Aβ42 was observed via saturation transfer difference-nuclear magnetic resonance (STD-NMR). In contrast, the hydrolysates gallic acid (2) and corilagin (5) showed aggregationinhibiting activity and binding was observed via STD-NMR. Therefore, the hydrolysates produced under the conditions of the activity test may contribute to the Aβ42 aggregation-inhibition activity of G. thunbergii extracts. Geraniin derivatives may help prevent and treat AD. |
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言語 | en | |||||||||||||||||||||||||||||
書誌情報 |
en : Bioorganic & Medicinal Chemistry 巻 68, p. 116840, 発行日 2022 |
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出版者 | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
出版者 | Elsevier | |||||||||||||||||||||||||||||
出版者版へのリンク | ||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||
https://doi.org/10.1016/j.bmc.2022.116840 | ||||||||||||||||||||||||||||||
DOI | ||||||||||||||||||||||||||||||
関連タイプ | isVersionOf | |||||||||||||||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||||||||||||||
関連識別子 | 10.1016/j.bmc.2022.116840 | |||||||||||||||||||||||||||||
ISSN | ||||||||||||||||||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||||||||||||||||||
収録物識別子 | 0968-0896 | |||||||||||||||||||||||||||||
権利 | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
権利情報 | © 2022 Elsevier Ltd | |||||||||||||||||||||||||||||
著者版フラグ | ||||||||||||||||||||||||||||||
出版タイプ | AM | |||||||||||||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |