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ロスマリン酸誘導体のAβ凝集阻害活性とその構造活性相関
http://hdl.handle.net/10258/00008619
http://hdl.handle.net/10258/000086190c2f8a2b-a37a-41b8-b12c-a8214009734c
名前 / ファイル | ライセンス | アクション |
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33_147.pdf (710.1 kB)
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Item type | 会議発表論文 / Conference Paper(1) | |||||||||||||||||||||||||||||
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公開日 | 2016-04-07 | |||||||||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||||||||
タイトル | ロスマリン酸誘導体のAβ凝集阻害活性とその構造活性相関 | |||||||||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
タイトル | Inhibitory effect of amyloid-beta aggregation on rosmarinic acid derivatives and their structure-activity relationship | |||||||||||||||||||||||||||||
言語 | ||||||||||||||||||||||||||||||
言語 | jpn | |||||||||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||||||||||||||||||||||||||
資源タイプ | conference paper | |||||||||||||||||||||||||||||
アクセス権 | ||||||||||||||||||||||||||||||
アクセス権 | open access | |||||||||||||||||||||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||||||
著者 |
田口, 莉帆
× 田口, 莉帆× 高橋, 倫人× 畑山, 晃輝× 橋, 友理香× 関, 千草
WEKO
43177
× 中野, 博人
WEKO
59463
× 徳樂, 清孝
WEKO
46701
× 上井, 幸司
WEKO
911
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室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||||||||
関 千草(SEKI Chigusa) | ||||||||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000264_ja.html | ||||||||||||||||||||||||||||||
室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||||||||
中野 博人(NAKANO Hiroto) | ||||||||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000161_ja.html | ||||||||||||||||||||||||||||||
室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||||||||
徳樂 清孝(TOKURAKU Kiyotaka) | ||||||||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000137_ja.html | ||||||||||||||||||||||||||||||
室蘭工業大学研究者データベースへのリンク | ||||||||||||||||||||||||||||||
上井 幸司(UWAI Koji) | ||||||||||||||||||||||||||||||
http://rdsoran.muroran-it.ac.jp/html/100000240_ja.html | ||||||||||||||||||||||||||||||
抄録 | ||||||||||||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||||||||||||
内容記述 | As the aggregation of Αβ peptide has been considered as one of the pathogenesis of Alzheimer's disease, development of the potent inhibitor has been required for its complete recovery. We have identified rosmarinic acid with a major Αβ aggregation inhibitor of summer savory, one of the member of Lamiaceae. Therefore, we designed several rosmarinic acid derivatives for anti-Αβ aggregation drug candidates. Anti-Αβ aggregation activity was evaluated by our developed method “micro littlers scale high-throughput screening (MSHTS) system”. The results showed the presence of the phenol hydroxyl group and hydrophobic alkoxy group is very important for the activity. The docking study between Αβ42 and synthesized compounds and their ThT assays are ongoing. The details of SAR studies of rosmarinic acid derivatives with Αβ42 will be presented. | |||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
書誌情報 |
ja : メディシナルケミストリーシンポジウム講演要旨集 en : Symposium on Medicinal Chemistry 巻 33, p. 147-147, 発行日 2015-11-01 |
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会議記述 | ||||||||||||||||||||||||||||||
会議名 | メディシナルケミストリーシンポジウム | |||||||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||||||||
注記 | ||||||||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||||||||
内容記述 | 2P-13 | |||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
出版者 | ||||||||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||||||||
出版者 | 日本薬学会医薬化学部会 | |||||||||||||||||||||||||||||
日本十進分類法 | ||||||||||||||||||||||||||||||
主題Scheme | NDC | |||||||||||||||||||||||||||||
主題 | 499 | |||||||||||||||||||||||||||||
ISSN | ||||||||||||||||||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||||||||||||||||||
収録物識別子 | 0919-214X | |||||||||||||||||||||||||||||
書誌レコードID | ||||||||||||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||||||||||||
収録物識別子 | AA1208032X | |||||||||||||||||||||||||||||
権利 | ||||||||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||||||||
権利情報 | © 2015 日本薬学会医薬化学部会 | |||||||||||||||||||||||||||||
著者版フラグ | ||||||||||||||||||||||||||||||
出版タイプ | VoR | |||||||||||||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||
フォーマット | ||||||||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||||||||
内容記述 | application/pdf |